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- Title
Two opposing modes of action of β-endorphin on lymphocyte function.
- Authors
Van Den Bergh, P.; Rozing, J.; Nagelkerken, L.
- Abstract
Five opioid peptides (α, β-, and γ-endorphin, methionine- and leucine-enkephalin) were tested for their effect on the concanavalin A-induced proliferative response of splenocytes of adult male F344 rats. The continuous presence of these opioid peptides during culture of T cells did not affect proliferation. However, 30 min of preincubation with β-endorphin (β-end), but not with the other opioid peptides, resulted in a dose-dependent enhancement of proliferation of 50-100%. This potentiating effect of, β-end on proliferation was preceded by an increase in the production of interleukin-2 (IL-2) and in the extent of IL-2 receptor expression. The stimulatory effect of β-end was not prevented by naloxone, indicating that classical opioid receptors were not involved. The continuous presence of β-end (or α-end) in cultures of cells that had been preincubated with β-end completely abolished the stimulatory effect, pointing towards the potential of β-end to regulate T-cell function via different mechanisms.
- Subjects
CELLULAR mechanics; PEPTIDES; T cells; METHIONINE; LEUCINE; RATS; IMMUNOLOGY
- Publication
Immunology, 1991, Vol 72, Issue 4, p537
- ISSN
0019-2805
- Publication type
Article