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- Title
Short-term microvascular response of striated muscle to cp-Ti, Ti-6Al-4V, and Ti-6Al-7Nb.
- Authors
Pennekamp, Peter H.; Gessmann, Jan; Diedrich, Oliver; Burian, Björn; Wimmer, Markus A.; Frauchiger, Vinzenz M.; Kraft, Clayton N.
- Abstract
Due to excellent mechanical properties and good corrosion resistance, titanium-aluminium-vanadium (Ti-6Al-4V) and titanium-aluminium-niobium (Ti-6Al-7Nb) are extensively used for orthopedic surgery. Concern has been voiced concerning the implications of the constituent vanadium in Ti-6Al-4V on the surrounding environment. Particularly in osteosynthesis where the alloys stand in direct contact to skeletal muscle, undesirable biologic reactions may have severe consequences. In a comparative study, we assessed in vivo nutritive perfusion and leukocytic response of striated muscle to the metals Ti-6Al-4V, Ti-6Al-7Nb, and commercially pure titanium (cpTi), thereby drawing conclusions on their short-term inflammatory potential. In 28 hamsters, utilizing the dorsal skinfold chamber preparation and intravital microscopy, we quantified primary and secondary leukocyte-endothelial cell interaction, leukocyte extravasation, microvascular diameter change, and capillary perfusion in collecting and postcapillary venules of skeletal muscle. A manifest discrepancy between the metals concerning impact on local microvascular parameters was not found. All metals induced an only transient and moderate inflammatory response. Only a slight increase in leukocyte recruitment and a more sluggish recuperation of inflammatory parameters in animals treated with Ti-6Al-4V compared to the other two metals suggested a minor, overall not significant discrepancy in biocompatibility. Gross toxicity of bulk Ti-6Al-4V on surrounding tissue could not be found. Conclusively, the commonly used biomaterials Ti-6Al-4V, Ti-6Al-7Nb, and cpTi induce an only transient inflammatory answer of the skeletal muscle microvascular system. Our results indicate that on the microvascular level the tested bulk Ti-alloys and cpTi do not cause adverse biologic reactions in striated muscle. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 24:531-540, 2006
- Subjects
TITANIUM; MICROCIRCULATION; BIOCOMPATIBILITY; MUSCLE physiology; ORTHOPEDIC surgery
- Publication
Journal of Orthopaedic Research, 2006, Vol 24, Issue 3, p531
- ISSN
0736-0266
- Publication type
Article
- DOI
10.1002/jor.20066