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- Title
Gene-Environment Interaction in Genome-Wide Association Studies.
- Authors
Cassandra E. Murcray; Juan Pablo Lewinger; W. James Gauderman
- Abstract
It is a commonly held belief that most complex diseases (e.g., diabetes, asthma, cancer) are affected in part by interactions between genes and environmental factors. However, investigators conducting genome-wide association studies typically test for only the marginal effects of each genetic marker on disease. In this paper, the authors propose an efficient and easily implemented 2-step analysis of genome-wide association study data aimed at identifying genes involved in a gene-environment interaction. The procedure complements screening for marginal genetic effects and thus has the potential to uncover new genetic signals that have not been identified previously.
- Subjects
GENOTYPE-environment interaction; HUMAN genome; ENVIRONMENTALLY induced diseases; GENETIC markers; MEDICAL genetics; ECOLOGICAL genetics; ETIOLOGY of diseases; DIABETES
- Publication
American Journal of Epidemiology, 2009, Vol 169, Issue 2, p219
- ISSN
0002-9262
- Publication type
Article