We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Serum Neutrophil Gelatinase-Associated Lipocalin and Cystatin C are early Biomarkers of Contrast-Induced Nephropathy After Coronary Angiography in Patients With Chronic Kidney Disease.
- Authors
Alharazy, Sabah Mohamed; Kong, Norella; Saidin, Rashidi; Gafor, Abdul Halim Abdul; Maskon, Oteh; Mohd, Marlyn; Zakaria, Syed Zulkifli Syed
- Abstract
We had previously reported on serum neutrophil gelatinase-associated lipocalin (NGAL) as an earlier biomarker of contrast-induced nephropathy (CIN) than serum creatinine (SCr) in 100 patients with chronic kidney disease undergoing coronary angiography.1 We then compared serum NGAL to serum cystatin C (CysC) in the same group of patients. The SCr, estimated glomerular filtration rate, serum NGAL, and serum CysC were measured at baseline and various time points as appropriate postprocedure. The frequency of CIN was 11% (n = 11). Serum NGAL increased ≥25% from baseline at 24 hours in 7 patients with CIN (P = .04). Serum CysC increased ≥25% from baseline at 24 hours in 4 patients with CIN (P = .008). Changes in serum NGAL and serum CysC from baseline at 24 hours (▵ values) could diagnose CIN 24 hours earlier than SCr with serum NGAL showing a superior performance.
- Subjects
CHRONIC kidney failure; ACUTE kidney failure; BIOMARKERS; CARRIER proteins; CONFIDENCE intervals; MATHEMATICAL statistics; NONPARAMETRIC statistics; PROTEINS; RESEARCH funding; STATISTICS; DATA analysis; PARAMETERS (Statistics); CONTRAST media; RECEIVER operating characteristic curves; DATA analysis software; DESCRIPTIVE statistics; CORONARY angiography; SURGERY
- Publication
Angiology, 2014, Vol 65, Issue 5, p436
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319713483918