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- Title
Long-Term Mortality and Major Adverse Cardiovascular Events in Sepsis Survivors. A Nationwide Population-based Study.
- Authors
Shuo-Ming Ou; Hsi Chu; Pei-Wen Chao; Yi-Jung Lee; Shu-Chen Kuo; Tzeng-Ji Chen; Ching-Min Tseng; Chia-Jen Shih; Yung-Tai Chen; Ou, Shuo-Ming; Chu, Hsi; Chao, Pei-Wen; Lee, Yi-Jung; Kuo, Shu-Chen; Chen, Tzeng-Ji; Tseng, Ching-Min; Shih, Chia-Jen; Chen, Yung-Tai
- Abstract
<bold>Rationale: </bold>Patients with sepsis who survive to hospital discharge may present with ongoing high morbidity and mortality. However, little is known about the risk of long-term, all-cause mortality and cardiovascular outcomes after sepsis.<bold>Objectives: </bold>Our study aimed to investigate the long-term clinical outcomes in sepsis survivors.<bold>Methods: </bold>In this nationwide population-based study, data from patients with sepsis were retrieved from Taiwan's National Health Insurance Research Database between 2000 and 2002. Each sepsis survivor was 1:1 propensity-matched to control subjects from two different control populations: subjects who were in the general population and subjects who were hospitalized for a nonsepsis diagnosis. The primary outcomes were all-cause mortality, major adverse cardiovascular events, myocardial infarction, heart failure, stroke, and sudden cardiac death or ventricular arrhythmia.<bold>Measurements and Main Results: </bold>Compared with matched population control subjects, sepsis survivors had higher risks of all-cause mortality (hazard ratio [HR], 2.18; 95% confidence interval [CI], 2.14-2.22), major adverse cardiovascular events (HR, 1.37; 95% CI, 1.34-1.41), ischemic stroke (HR, 1.27; 95% CI, 1.23-1.32), hemorrhagic stroke (HR, 1.36; 95% CI, 1.26-1.46), myocardial infarction (HR, 1.22; 95% CI, 1.14-1.30), heart failure (HR, 1.48; 95% CI, 1.43-1.53), and sudden cardiac death or ventricular arrhythmia (HR, 1.65; 95% CI, 1.57-1.74). Similar results, although slightly attenuated risks, were found when comparisons were made with hospitalized control subjects without sepsis.<bold>Conclusions: </bold>These data indicate that sepsis survivors had substantially increased risks of subsequent all-cause mortality and major adverse cardiovascular events at 1 year after discharge, which persisted for up to 5 years after discharge.
- Subjects
TAIWAN; CARDIOVASCULAR diseases; SEPSIS; PROPORTIONAL hazards models
- Publication
American Journal of Respiratory & Critical Care Medicine, 2016, Vol 194, Issue 2, p209
- ISSN
1073-449X
- Publication type
journal article
- DOI
10.1164/rccm.201510-2023OC