We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
COVID-19 Pneumonia in Fully Vaccinated Adults during the Dominance of the Omicron Sublineages BA.1.1 and BA.2 in Mexico.
- Authors
Murillo-Zamora, Efrén; Trujillo, Xóchitl; Huerta, Miguel; Riós-Silva, Mónica; Guzmán-Esquivel, José; Bricio-Barrios, Jaime Alberto; Mendoza-Cano, Oliver; Lugo-Radillo, Agustin
- Abstract
Background and Objectives: A nationwide retrospective cohort study was conducted to evaluate the factors associated with the risk of laboratory-confirmed coronavirus disease 2019 (COVID-19)-related pneumonia in fully vaccinated adults during the dominance of the Omicron sublineages in Mexico. Materials and Methods: Fully COVID-19-vaccinated adults with laboratory-positive illness and symptom onset from April to mid-June 2022 were eligible. We computed the eta-squared (η2) to evaluate the effect size of the study sample. The characteristics predicting pneumonia were evaluated through risk ratios (RRs), and the 95% confidence intervals (CIs) were computed through generalized linear models. Results: The data from 35,561 participants were evaluated, and the overall risk of pneumonia was 0.5%. In multiple analyses, patients aged ≥ 60 years old were at increased risk of developing pneumonia (vs. 20–39 years old: RR = 1.031, 95% CI = 1.027–1.034). Chronic pulmonary obstructive disease, type 2 diabetes mellitus, arterial hypertension, chronic kidney disease (any stage), and immunosuppression (any cause) were also associated with a higher pneumonia risk. The η2 of all the variables included in the multiple models was <0.06. Conclusions: Our study suggests that, even when fully COVID-19-vaccinated, older adults and those with chronic conditions were at increased risk of pneumonia during the dominance of the Omicron sublineages BA.1.1 and BA.2.
- Subjects
MEXICO; SARS-CoV-2 Omicron variant; DIABETIC nephropathies; CORONAVIRUS diseases; COVID-19; TYPE 2 diabetes; CHRONIC obstructive pulmonary disease; PNEUMONIA
- Publication
Medicina (1010660X), 2022, Vol 58, Issue 8, p1127
- ISSN
1010-660X
- Publication type
Article
- DOI
10.3390/medicina58081127