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- Title
Development of a New Magnetometer for Sentinel Lymph Node Mapping Designed for Video-Assisted Thoracic Surgery in Non–Small Cell Lung Cancer.
- Authors
Imai, Kazuhiro; Kawaharada, Yasushi; Ogawa, Jun-ichi; Saito, Hajime; Kudo, Satoshi; Takashima, Shinogu; Saito, Yoshitaro; Atari, Maiko; Ito, Aki; Terata, Kaori; Yoshino, Kei; Sato, Yusuke; Motoyama, Satoru; Minamiya, Yoshihiro
- Abstract
Background. We previously developed a method for sentinel lymph node (SLN) mapping in non–small cell lung cancer (NSCLC), based on the magnetic force produced by a magnetite tracer already approved for use as a contrast material for magnetic resonance imaging. However, it is difficult to use that technique with video-assisted thoracic surgery (VATS) because the sensing element of the magnetometer is large and thick. The purpose of the present study was to develop a smaller, thinner VATS-compatible magnetometer. Methods. The tracer employed was Ferucarbotran, a colloidal solution of superparamagnetic iron oxide coated with carbodextran. Fifteen patients with clinical stage I NSCLC were enrolled, and each received 1.6 mL of Ferucarbotran, injected intraoperatively at 5 points around the tumor. The magnetic force within the sampling lymph nodes was measured using the new VATS-compatible magnetometer. Results. SLNs were detected in 11 (73.3%) of the 15 patients using the VATS-compatible magnetometer. The average number of SLNs identified per patient was 1.8 (range 0-4). No complications related to the SLN detection method were observed. Conclusions. The new VATS-compatible magnetometer appears to have substantial advantages over techniques using a radioisotope and our earlier magnetometer, as it can be inserted through the small VATS port site.
- Publication
Surgical Innovation, 2015, Vol 22, Issue 4, p401
- ISSN
1553-3506
- Publication type
Article
- DOI
10.1177/1553350615585421