We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
OX40+ plasmacytoid dendritic cells in the tumor microenvironment promote antitumor immunity.
- Authors
Poropatich, Kate; Dominguez, Donye; Wen-Ching Chan; Andrade, Jorge; Yuanyuan Zha; Wray, Brian; Miska, Jason; Lei Qin; Cole, Lisa; Coates, Sydney; Patel, Urjeet; Samant, Sandeep; Bin Zhang; Chan, Wen-Ching; Zha, Yuanyuan; Qin, Lei; Zhang, Bin
- Abstract
Plasmacytoid DCs (pDCs), the major producers of type I interferon, are principally recognized as key mediators of antiviral immunity. However, their role in tumor immunity is less clear. Depending on the context, pDCs can promote or suppress antitumor immune responses. In this study, we identified a naturally occurring pDC subset expressing high levels of OX40 (OX40+ pDC) enriched in the tumor microenvironment (TME) of head and neck squamous cell carcinoma. OX40+ pDCs were distinguished by a distinct immunostimulatory phenotype, cytolytic function, and ability to synergize with conventional DCs (cDCs) in generating potent tumor antigen-specific CD8+ T cell responses. Transcriptomically, we found that they selectively utilized EIF2 signaling and oxidative phosphorylation pathways. Moreover, depletion of pDCs in the murine OX40+ pDC-rich tumor model accelerated tumor growth. Collectively, we present evidence of a pDC subset in the TME that favors antitumor immunity.
- Subjects
ANIMAL experimentation; CELL lines; CELL physiology; CELL receptors; COMPARATIVE studies; DENDRITIC cells; RESEARCH methodology; MEDICAL cooperation; MICE; PROTEINS; RESEARCH; T cells; TUMOR antigens; TUMORS; EVALUATION research
- Publication
Journal of Clinical Investigation, 2020, Vol 130, Issue 7, p3528
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI131992