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- Title
Ushering in the cardiac role of Ubiquilin1.
- Authors
Xi Fang; Trexler, Christa; Ju Chen; Fang, Xi; Chen, Ju
- Abstract
Protein quality control (PQC) mechanisms are essential for maintaining cardiac function, and alterations in this pathway influence multiple forms of heart disease. Since heart disease is the leading cause of death worldwide, understanding how the delicate balance between protein synthesis and degradation is regulated in the heart demands attention. The study by Hu et al. reveals that the extraproteasomal ubiquitin receptor Ubiquilin1 (Ubqln1) plays an important role in cardiac ubiquitination-proteasome coupling, particularly in response to myocardial ischemia/reperfusion injury, thereby suggesting that this may be a new avenue for therapeutics.
- Subjects
CARDIOLOGY; QUALITY control; CORONARY disease; DEATH; PROTEIN synthesis; PROTEOLYSIS; REPERFUSION injury
- Publication
Journal of Clinical Investigation, 2018, Vol 128, Issue 12, p5195
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI124567