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- Title
Viruses and human brain tumors: cytomegalovirus enters the fray.
- Authors
Hawkins, Cynthia; Croul, Sidney
- Abstract
Medulloblastoma is the most common malignant brain tumor in children. Overall survival rates have improved in recent years as a result of risk-stratified treatment regimens. However, medulloblastoma remains associated with substantial mortality, and survivors often experience debilitating neurological, endocrinological, and social sequelae as a result of treatment. Targeted and less toxic therapeutic strategies are therefore needed. In this issue of the JCI, Baryawno et al. report their findings that a large percentage of primary medulloblastomas and medulloblastoma cell lines are infected with human cytomegalovirus (HCMV) and suggest that targeting this virus could provide a new way to treat individuals with medulloblastoma.
- Subjects
MEDULLOBLASTOMA; BRAIN tumors; MORTALITY; ENDOCRINOLOGY; CELL lines; CYTOMEGALOVIRUSES; ANIMAL experimentation; COMPARATIVE studies; GLIOMAS; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; EVALUATION research
- Publication
Journal of Clinical Investigation, 2011, Vol 121, Issue 10, p3831
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI60005