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GlaxoSmithKline responds to the consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes.
Published in:
2009
By:
- Ambery, P.;
- Cobitz, A.
Publication type:
Letter
The drug interaction potential of daprodustat when coadministered with pioglitazone, rosuvastatin, or trimethoprim in healthy subjects.
Published in:
Pharmacology Research & Perspectives, 2018, v. 6, n. 2, p. 1, doi. 10.1002/prp2.327
By:
- Caltabiano, Stephen;
- Mahar, Kelly M.;
- Lister, Karyn;
- Tenero, David;
- Ravindranath, Ramiya;
- Cizman, Borut;
- Cobitz, Alexander R.
Publication type:
Article
Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients: A Randomized Clinical Trial.
Published in:
2022
By:
- Singh, Ajay K.;
- Cizman, Borut;
- Carroll, Kevin;
- McMurray, John J. V.;
- Perkovic, Vlado;
- Jha, Vivekanand;
- Johansen, Kirsten L.;
- Lopes, Renato D.;
- Macdougall, Iain C.;
- Obrador, Gregorio T.;
- Waikar, Sushrut S.;
- Wanner, Christoph;
- Wheeler, David C.;
- Wiecek, Andrzej;
- Stankus, Nicole;
- Strutz, Frank;
- Blackorby, Allison;
- Cobitz, Alexander R.;
- Meadowcroft, Amy M.;
- Paul, Gitanjali
Publication type:
journal article
Pharmacokinetics of Daprodustat and Metabolites in Individuals with Normal and Impaired Hepatic Function.
Published in:
Clinical Pharmacology in Drug Development, 2022, v. 11, n. 5, p. 562, doi. 10.1002/cpdd.1090
By:
- Mahar, Kelly M.;
- Shaddinger, Bonnie C.;
- Ramanjineyulu, Bandi;
- Andrews, Susan;
- Caltabiano, Stephen;
- Lindsay, Alistair C.;
- Cobitz, Alexander R.
Publication type:
Article
Clinical Pharmacokinetics of Daprodustat: Results of an Absorption, Distribution, and Excretion Study With Intravenous Microtracer and Concomitant Oral Doses for Bioavailability Determination.
Published in:
Clinical Pharmacology in Drug Development, 2021, v. 10, n. 12, p. 1419, doi. 10.1002/cpdd.1029
By:
- Mahar, Kelly M.;
- Caltabiano, Stephen;
- Andrews, Susan;
- Ramanjineyulu, Bandi;
- Chen, Liangfu;
- Young, Graeme;
- Pereira, Adrian;
- Lindsay, Alistair C.;
- van den Berg, Frans;
- Cobitz, Alexander R.
Publication type:
Article
A Randomized, Placebo‐ and Positive‐Controlled, Single‐Dose, Crossover Thorough QT/QTc Study Assessing the Effect of Daprodustat on Cardiac Repolarization in Healthy Subjects.
Published in:
Clinical Pharmacology in Drug Development, 2017, v. 6, n. 6, p. 627, doi. 10.1002/cpdd.342
By:
- Caltabiano, Stephen;
- Collins, Jon;
- Serbest, Gul;
- Morgan, Lisa;
- Smith, Deborah A.;
- Ravindranath, Ramiya;
- Cobitz, Alexander R.
Publication type:
Article
Analysis of on-treatment cancer safety events with daprodustat versus conventional erythropoiesis-stimulating agents—post hoc analyses of the ASCEND-ND and ASCEND-D trials.
Published in:
Nephrology Dialysis Transplantation, 2023, v. 38, n. 8, p. 1890, doi. 10.1093/ndt/gfac342
By:
- Singh, Ajay K;
- McCausland, Finnian R;
- Claggett, Brian L;
- Wanner, Christoph;
- Wiecek, Andrzej;
- Atkins, Michael B;
- Carroll, Kevin;
- Perkovic, Vlado;
- McMurray, John J V;
- Wittes, Janet;
- Snapinn, Steven;
- Blackorby, Allison;
- Meadowcroft, Amy;
- Barker, Tara;
- DiMino, Tara;
- Mallett, Stephen;
- Cobitz, Alexander R;
- Solomon, Scott D
Publication type:
Article
ASCEND-ND trial: study design and participant characteristics.
Published in:
Nephrology Dialysis Transplantation, 2022, v. 37, n. 11, p. 2157, doi. 10.1093/ndt/gfab318
By:
- Perkovic, Vlado;
- Blackorby, Allison;
- Cizman, Borut;
- Carroll, Kevin;
- Cobitz, Alexander R;
- Davies, Rich;
- DiMino, Tara L;
- Jha, Vivekanand;
- Johansen, Kirsten L;
- Lopes, Renato D;
- Kler, Lata;
- Macdougall, Iain C;
- McMurray, John J V;
- Meadowcroft, Amy M;
- Obrador, Gregorio T;
- Solomon, Scott;
- Taft, Lin;
- Wanner, Christoph;
- Waikar, Sushrut S;
- Wheeler, David C
Publication type:
Article
Study design and baseline characteristics of patients on dialysis in the ASCEND-D trial.
Published in:
Nephrology Dialysis Transplantation, 2022, v. 37, n. 5, p. 960, doi. 10.1093/ndt/gfab065
By:
- Singh, Ajay K;
- Blackorby, Allison;
- Cizman, Borut;
- Carroll, Kevin;
- Cobitz, Alexander R;
- Davies, Rich;
- Jha, Vivekanand;
- Johansen, Kirsten L;
- Lopes, Renato D;
- Kler, Lata;
- Macdougall, Iain C;
- McMurray, John J V;
- Meadowcroft, Amy M;
- Obrador, Gregorio T;
- Perkovic, Vlado;
- Solomon, Scott;
- Wanner, Christoph;
- Waikar, Sushrut S;
- Wheeler, David C;
- Wiecek, Andrzej
Publication type:
Article
Comparison of Two Manufacturing Processes of Daprodustat for Bioequivalence and Dissolution in Healthy Volunteers: A Randomized Crossover Study.
Published in:
Clinical Pharmacology in Drug Development, 2023, v. 12, n. 7, p. 739, doi. 10.1002/cpdd.1257
By:
- Shaddinger, Bonnie;
- Mahar, Kelly M.;
- Sprys, Mike;
- Andrews, Susan M.;
- Chattoraj, Sayantan;
- Israni, Rubeen;
- Cobitz, Alex
Publication type:
Article
A randomized, parallel group, double-blind, multicentre study comparing the efficacy and safety of Avandamet (rosiglitazone/metformin) and metformin on long-term glycaemic control and bone mineral density after 80 weeks of treatment in drug-na ïve type 2 diabetes mellitus patients
Published in:
Diabetes, Obesity & Metabolism, 2011, v. 13, n. 11, p. 1036, doi. 10.1111/j.1463-1326.2011.01461.x
By:
- Borges, J. L. C.;
- Bilezikian, J. P.;
- Jones-Leone, A. R.;
- Acusta, A. P.;
- Ambery, P. D.;
- Nino, A. J.;
- Grosse, M.;
- Fitzpatrick, L. A.;
- Cobitz, A. R.
Publication type:
Article
Improvement in glycaemic control with rosiglitazone/metformin fixed-dose combination therapy in patients with type 2 diabetes with very poor glycaemic control.
Published in:
Diabetes, Obesity & Metabolism, 2006, v. 8, n. 6, p. 643, doi. 10.1111/j.1463-1326.2006.00648.x
By:
- Rosenstock, J.;
- Rood, J.;
- Cobitz, A.;
- Huang, C.;
- Garber, A.
Publication type:
Article
Initial treatment with rosiglitazone/metformin fixed-dose combination therapy compared with monotherapy with either rosiglitazone or metformin in patients with uncontrolled type 2 diabetes.
Published in:
Diabetes, Obesity & Metabolism, 2006, v. 8, n. 6, p. 650, doi. 10.1111/j.1463-1326.2006.00659.x
By:
- Rosenstock, J.;
- Rood, J.;
- Cobitz, A.;
- Biswas, N.;
- Chou, H.;
- Garber, A.
Publication type:
Article
Rosiglitazone decreases bone mineral density and increases bone turnover in postmenopausal women with type 2 diabetes mellitus.
Published in:
2013
By:
- Bilezikian, John P;
- Josse, Robert G;
- Eastell, Richard;
- Lewiecki, E Michael;
- Miller, Colin G;
- Wooddell, Margaret;
- Northcutt, Allison R;
- Kravitz, Barbara G;
- Paul, Gitanjali;
- Cobitz, Alexander R;
- Nino, Antonio J;
- Fitzpatrick, Lorraine A
Publication type:
Journal Article
Anemia and mortality in patients with nondialysis-dependent chronic kidney disease.
Published in:
2018
By:
- Stirnadel-Farrant, Heide A.;
- Luo, Jiacong;
- Kler, Lata;
- Cizman, Borut;
- Jones, Delyth;
- Brunelli, Steven M.;
- Cobitz, Alexander R.
Publication type:
journal article
Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury.
Published in:
2018
By:
- Billin, Andrew N.;
- Honeycutt, Samuel E.;
- McDougal, Alan V.;
- Kerr, Jaclyn P.;
- Chen, Zhe;
- Freudenberg, Johannes M.;
- Rajpal, Deepak K.;
- Luo, Guizhen;
- Kramer, Henning Fritz;
- Geske, Robert S.;
- Fang, Frank;
- Yao, Bert;
- Clark, Richard V.;
- Lepore, John;
- Cobitz, Alex;
- Miller, Ram;
- Nosaka, Kazunori;
- Hinken, Aaron C.;
- Russell, Alan J.
Publication type:
Correction Notice
HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury.
Published in:
Skeletal Muscle, 2018, v. 8, n. 1, p. N.PAG, doi. 10.1186/s13395-018-0179-5
By:
- Billin, Andrew N.;
- Honeycutt, Samuel E.;
- McDougal, Alan V.;
- Kerr, Jaclyn P.;
- Chen, Zhe;
- Freudenberg, Johannes M.;
- Rajpal, Deepak K.;
- Luo, Guizhen;
- Kramer, Henning Fritz;
- Geske, Robert S.;
- Fang, Frank;
- Yao, Bert;
- Clark, Richard V.;
- Lepore, John;
- Cobitz, Alex;
- Miller, Ram;
- Nosaka, Kazunori;
- Hinken, Aaron C.;
- Russell, Alan J.
Publication type:
Article
Posttranslational modification of ras proteins: Detection of a modification prior to fatty acid acylation and cloning of a gene responsible for the modification.
Published in:
Journal of Cellular Biochemistry, 1988, v. 36, n. 3, p. 261, doi. 10.1002/jcb.240360307
By:
- Tamanoi, F.;
- Hsueh, E. C.;
- Goodman, L. E.;
- Cobitz, A. R.;
- Detrick, R. J.;
- Brown, W. R.;
- Fujiyama, A.
Publication type:
Article
Rosiglitazone increases LDL particle size and buoyancy and decreases C-reactive protein in patients with type 2 diabetes on statin therapy.
Published in:
Diabetes & Vascular Disease Research, 2006, v. 3, n. 3, p. 189, doi. 10.3132/dvdr.2006.029
By:
- Yu, Dahong;
- Murdoch, Susan J;
- Parikh, Shamik J;
- Marcovina, Santica M;
- Cobitz, Alexander;
- Chen, Hongzi;
- Brunzell, John D
Publication type:
Article
Improving Metabolic Control Leads to Better Working Memory in Adults With Type 2 Diabetes.
Published in:
Diabetes Care, 2006, v. 29, n. 2, p. 345, doi. 10.2337/diacare.29.02.06.dc05-1626
By:
- Ryan, Christopher M.;
- Freed, Martin I.;
- Rood, Julie A.;
- Cobitz, Alexander R.;
- Waterhouse, Brian R.;
- Strachan, Mark W. J.
Publication type:
Article
Effect of renal function and dialysis modality on daprodustat and predominant metabolite exposure.
Published in:
Clinical Kidney Journal, 2019, v. 12, n. 5, p. 693, doi. 10.1093/ckj/sfz013
By:
- Caltabiano, Stephen;
- Cizman, Borut;
- Burns, Olivia;
- Mahar, Kelly M;
- Johnson, Brendan M;
- Ramanjineyulu, Bandi;
- Serbest, Gulyeter;
- Cobitz, Alexander R
Publication type:
Article
Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis.
Published in:
Clinical Kidney Journal, 2019, v. 12, n. 1, p. 139, doi. 10.1093/ckj/sfy014
By:
- Meadowcroft, Amy M;
- Cizman, Borut;
- Holdstock, Louis;
- Biswas, Nandita;
- Johnson, Brendan M;
- Jones, Delyth;
- Nossuli, A Kaldun;
- Lepore, John J;
- Aarup, Michael;
- Cobitz, Alexander R
Publication type:
Article
Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants with chronic kidney disease.
Published in:
Clinical Kidney Journal, 2019, v. 12, n. 1, p. 129, doi. 10.1093/ckj/sfy013
By:
- Holdstock, Louis;
- Cizman, Borut;
- Meadowcroft, Amy M;
- Biswas, Nandita;
- Johnson, Brendan M;
- Jones, Delyth;
- Kim, Sung Gyun;
- Zeig, Steven;
- Lepore, John J;
- Cobitz, Alexander R
Publication type:
Article
Normalization of skeletal muscle glycogen synthesis and glycolysis in rosiglitazone-treated Zucker fatty rats: an in vivo nuclear magnetic resonance study.
Published in:
2002
By:
- Jucker, Beat M.;
- Schaeffer, Thomas R.;
- Haimbach, Robin E.;
- McIntosh, Thomas S.;
- Chun, Daniel;
- Mayer, Matthew;
- Ohlstein, Derek H.;
- Davis, Hugh M.;
- Smith, Stephen A.;
- Cobitz, Alexander R.;
- Sarkar, Susanta K.
Publication type:
journal article
Commentary on 'case series of liver failure associated with rosiglitazone and pioglitazone' by Floyd et al.
Published in:
Pharmacoepidemiology & Drug Safety, 2009, v. 18, n. 12, p. 1244, doi. 10.1002/pds.1840
By:
- Osei, Suzette Y;
- Koro, Carol E;
- Cobitz, Alexander R;
- Kolatkar, Nikheel S;
- Stender, Monika
Publication type:
Article
A retrospective evaluation of congestive heart failure and myocardial ischemia events in 14 237 patients with type 2 diabetes mellitus enrolled in 42 short-term, double-blind, randomized clinical studies with rosiglitazone.
Published in:
Pharmacoepidemiology & Drug Safety, 2008, v. 17, n. 8, p. 769, doi. 10.1002/pds.1615
By:
- Cobitz, Alexander;
- Zambanini, Andrew;
- Sowell, Margaret;
- Heise, Mark;
- Louridas, Bonnie;
- McMorn, Stephen;
- Semigran, Marc;
- Koch, Gary
Publication type:
Article
Regional Variation of Erythropoiesis-Stimulating Agent Hyporesponsiveness in the Global Daprodustat Dialysis Study (ASCEND-D).
Published in:
American Journal of Nephrology, 2023, v. 54, n. 1/2, p. 1, doi. 10.1159/000528696
By:
- Macdougall, Iain C.;
- Meadowcroft, Amy M.;
- Blackorby, Allison;
- Cizman, Borut;
- Cobitz, Alexander R.;
- Godoy, Sergio;
- Jha, Vivekanand;
- Johansen, Kirsten L.;
- McMahon, Gearoid;
- Obrador, Gregorio T.;
- Wong, Muh Geot;
- Singh, Ajay K.
Publication type:
Article
Daprodustat Compared with Epoetin Beta Pegol for Anemia in Japanese Patients Not on Dialysis: A 52-Week Randomized Open-Label Phase 3 Trial.
Published in:
American Journal of Nephrology, 2021, v. 52, n. 1, p. 26, doi. 10.1159/000513103
By:
- Nangaku, Masaomi;
- Hamano, Takayuki;
- Akizawa, Tadao;
- Tsubakihara, Yoshiharu;
- Nagai, Reiko;
- Okuda, Nobuhiko;
- Kurata, Kyo;
- Nagakubo, Takashi;
- Jones, Nigel P.;
- Endo, Yukihiro;
- Cobitz, Alexander R.
Publication type:
Article
Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects.
Published in:
2017
By:
- akizawa, Tadao;
- Tsubakihara, Yoshiharu;
- Nangaku, Masaomi;
- Endo, Yukihiro;
- Nakajima, Hiromu;
- Kohno, Tomoko;
- Imai, Yukiko;
- Kawase, Natsumi;
- Hara, Katsutoshi;
- Lepore, John;
- Cobitz, alexander
Publication type:
journal article
A randomized, 29-day, dose-ranging, efficacy and safety study of daprodustat, administered three times weekly in patients with anemia on hemodialysis.
Published in:
2019
By:
- Bailey, Christine K.;
- Caltabiano, Stephen;
- Cobitz, Alexander R.;
- Huang, Chun;
- Mahar, Kelly M.;
- Patel, Vickas V.
Publication type:
journal article
Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Response to Nathan et al.
Published in:
2009
By:
- Cobitz AR;
- Ambery P
Publication type:
Journal Article
Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement of the American Diabetes Association and the European Association for the Study of Diabetes.
Published in:
Diabetes Care, 2009, v. 32, n. 5, p. e58, doi. 10.2337/dc09-0125
By:
- COBITZ, ALEXANDER R.;
- AMBERY, PHIL
Publication type:
Article
Safety of daprodustat in patients with anemia of chronic kidney disease: A pooled analysis of phase 3 studies in Japan.
Published in:
Therapeutic Apheresis & Dialysis, 2022, v. 26, n. 6, p. 1065, doi. 10.1111/1744-9987.13839
By:
- Nangaku, Masaomi;
- Akizawa, Tadao;
- Nagakubo, Takashi;
- Yonekawa, Taeko;
- Kimura, Toshifumi;
- Endo, Yukihiro;
- Cobitz, Alexander
Publication type:
Article
Efficacy and safety of daprodustat in Japanese peritoneal dialysis patients.
Published in:
Therapeutic Apheresis & Dialysis, 2021, v. 25, n. 6, p. 979, doi. 10.1111/1744-9987.13686
By:
- Hidetoshi Kanai;
- Masaomi Nangaku;
- Reiko Nagai;
- Nobuhiko Okuda;
- Kyo Kurata;
- Takashi Nagakubo;
- Yukihiro Endo;
- Cobitz, Alexander
Publication type:
Article
A 24‐Week Anemia Correction Study of Daprodustat in Japanese Dialysis Patients.
Published in:
Therapeutic Apheresis & Dialysis, 2020, v. 24, n. 2, p. 108, doi. 10.1111/1744-9987.12962
By:
- Tsubakihara, Yoshiharu;
- Akizawa, Tadao;
- Nangaku, Masaomi;
- Onoue, Tomohiro;
- Yonekawa, Taeko;
- Matsushita, Hideki;
- Endo, Yukihiro;
- Cobitz, Alexander
Publication type:
Article
Characterization of chronic and acute ESA hyporesponse: a retrospective cohort study of hemodialysis patients.
Published in:
BMC Nephrology, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s12882-015-0138-x
By:
- Sibbel, Scott P.;
- Koro, Carol E.;
- Brunelli, Steven M.;
- Cobitz, Alexander R.
Publication type:
Article
Characterization of chronic and acute ESA hyporesponse: a retrospective cohort study of hemodialysis patients.
Published in:
2015
By:
- Sibbel, Scott P;
- Koro, Carol E;
- Brunelli, Steven M;
- Cobitz, Alexander R
Publication type:
journal article

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