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- Title
The Partial O-Demethylation of Aromatic-Substituted 3,4-Dihydroisoquinolines.
- Authors
Brossi, A.; Teitel, S.
- Abstract
A detailed study has shown that all possible aromatic dimethoxy-substituted 3,4-dihydroisoquinolines can be partially O-demethylated by controlled acid hydrolysis. Based on the structure elucidation of the monophenols thus obtained, it was established that preferential cleavage occurs at the 5-methoxyl with the 5,6- and 5,8-isomers 1 and 3, respectively, at the 6-methoxyl with the 6,8-isomer 4, at the 7-methoxyl with the 5,7-isomer 5, and at the 8-methoxyl with the 7,8-isomer 2.
- Publication
Helvetica Chimica Acta, 1970, Vol 53, Issue 7, p1779
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19700530726