We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
High-Dose Deltamethrin Induces Developmental Toxicity in Caenorhabditis elegans via IRE-1.
- Authors
Chen, Chuhong; Deng, Ying; Liu, Linyan; Zou, Zhenyan; Jin, Chenzhong; Chen, Zhiyin; Wang, Shuanghui
- Abstract
Deltamethrin (DM), a Type II pyrethroid, is widely used worldwide in agriculture, household applications, and medicine. Recent studies have shown that DM exerts a variety of toxic effects on organs such as the kidney, heart muscle, and nerves in animals. However, little is known about the effects of high-dose DM on growth and development, and the mechanism of toxicity remains unclear. Using the Caenorhabditis elegans model, we found that high-dose DM caused a delay in nematode development. Our results showed that high-dose DM reduced the activation of the endoplasmic reticulum unfolded protein response (UPRER). Further studies revealed that high-dose DM-induced developmental toxicity and reduced capacity for UPRER activation were associated with the IRE-1/XBP-1 pathway. Our results provide new evidence for the developmental toxicity of DM and new insights into the mechanism of DM toxicity.
- Subjects
DELTAMETHRIN; POISONS; DENATURATION of proteins; MYOCARDIUM; ENDOPLASMIC reticulum; CYPERMETHRIN; CAENORHABDITIS; CAENORHABDITIS elegans; PYRETHROIDS
- Publication
Molecules, 2023, Vol 28, Issue 17, p6303
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28176303