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- Title
The Corey-Seebach Reagent in the 21st Century: A Review.
- Authors
Haroon, Muhammad; Zahoor, Ameer Fawad; Ahmad, Sajjad; Mansha, Asim; Irfan, Muhammad; Mushtaq, Aqsa; Akhtar, Rabia; Irfan, Ali; Kotwica-Mojzych, Katarzyna; Mojzych, Mariusz
- Abstract
The Corey-Seebach reagent plays an important role in organic synthesis because of its broad synthetic applications. The Corey-Seebach reagent is formed by the reaction of an aldehyde or a ketone with 1,3-propane-dithiol under acidic conditions, followed by deprotonation with n-butyllithium. A large variety of natural products (alkaloids, terpenoids, and polyketides) can be accessed successfully by utilizing this reagent. This review article focuses on the recent contributions (post-2006) of the Corey-Seebach reagent towards the total synthesis of natural products such as alkaloids (lycoplanine A, diterpenoid alkaloids, etc.), terpenoids (bisnorditerpene, totarol, etc.), polyketide (ambruticin J, biakamides, etc.), and heterocycles such as rodocaine and substituted pyridines, as well and their applications towards important organic synthesis.
- Subjects
TWENTY-first century; KETONES; ORGANIC synthesis; NATURAL products; POLYKETIDES; PROTON transfer reactions
- Publication
Molecules, 2023, Vol 28, Issue 11, p4367
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28114367