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- Title
Transplacental transfer of ritodrine and its effect on placental glucose and oxygen consumption in an in vitro human placental cotyledon perfusion.
- Authors
Urbach, Jacob; Mor, Lea; Fuchs, Sonia; Brandes, Joseph M.; Urbach, J; Mor, L; Fuchs, S; Brandes, J M
- Abstract
Maternofetal transfer of ritodrine and its effect on placental glucose and oxygen consumption were studied using a recycling perfusion of maternal and fetal circulations of an isolated cotyledon of a term human placenta. 3H-labeled ritodrine was introduced into the maternal side of the perfusion system. Transfer was calculated from the linear rise of ritodrine concentrations on the fetal side and was found to be 7.31 +/- 1.02 ng/g placental wet weight/min (SEM) when 1.4 micrograms/ml of ritodrine was used (n = 3) and 14.7 +/- 1.06 ng/g placental wet weight/min when the concentration was 2.8 micrograms/ml (n = 5). The antipyrine transfer rate, 4.1 +/- 0.51 mg/kg/min (n = 8), was used to demonstrate perfusion adequacy and served as an internal standard. Upon computing the mass balance of ritodrine and antipyrine at the end of the experiment, it was found that 17% of ritodrine disappeared from the perfusion system compared to 0.7% of antipyrine (p less than 0.01). The introduction of ritodrine into the perfusion system did not affect placental glucose and oxygen consumption rates of 0.35 +/- 0.01 mumol/g/min (n = 7) and 0.19 +/- 0.013 mumol/g/min (n = 5), respectively.
- Subjects
GLUCOSE analysis; GLUCOSE metabolism; ANTHROPOMETRY; PHYSICAL &; theoretical chemistry; COMPARATIVE studies; DRUG design; CLINICAL drug trials; HETEROCYCLIC compounds; MATERNAL-fetal exchange; RESEARCH methodology; MEDICAL cooperation; PLACENTA; RESEARCH; RITODRINE; EVALUATION research; OXYGEN consumption; IN vitro studies; PHARMACODYNAMICS; ANATOMY
- Publication
Gynecologic & Obstetric Investigation, 1991, Vol 32, Issue 1, p10
- ISSN
0378-7346
- Publication type
journal article
- DOI
10.1159/000292983