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- Title
Human antibodies to the polymorphic block 2 domain of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) exhibit a highly skewed, peptide-specific light chain distribution.
- Authors
Jouin, Hélène; Garraud, Olivier; Longacre, Shirley; Baleux, Françoise; Mercereau-Puijalon, Odile; Milon, Geneviève
- Abstract
Antibodies to polymorphic block 2 of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) present a paradoxical association with acquired protection against clinical malaria, while showing restricted and fixed specificity, reminiscent of antigenic sin. We report here that these antibodies present a highly imbalanced, peptide-specific light chain distribution. This was not observed with several other parasite-derived peptides or antigens. These data point to a skewed immune response to MSP-1 block 2 that is constrained both in specificity and chain usage. This is the first report of a biased response to polymorphic epitopes of a surface antigen in malaria parasites.
- Subjects
PLASMODIUM falciparum; IMMUNOGLOBULINS; MALARIA; PROTEINS; EPITOPES; ANTIGENS
- Publication
Immunology & Cell Biology, 2005, Vol 83, Issue 4, p392
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1111/j.1440-1711.2005.01343.x