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- Title
Mortality trends in an ambulatory multidisciplinary heart failure unit from 2001 to 2018.
- Authors
Spitaleri, Giosafat; Lupón, Josep; Domingo, Mar; Santiago-Vacas, Evelyn; Codina, Pau; Zamora, Elisabet; Cediel, Germán; Santesmases, Javier; Diez-Quevedo, Crisanto; Troya, Maria Isabel; Boldo, Maria; Altmir, Salvador; Alonso, Nuria; González, Beatriz; Núñez, Julio; Bayes-Genis, Antoni
- Abstract
To assess mortality trends at 1 and 3 years from 2001 to 2018 in a real-life cohort of HF outpatients from different etiologies with depressed and preserved LVEF. A total of 2368 consecutive patients with HF (mean age 66.4 ± 12.9 years, 71% men, 15.4% with preserved LVEF) admitted to a HF clinic from August 2001 to September 2018 were included in the study. Patients were divided into five quintiles (Q) according to the period of admission. Trends for all-cause and cardiovascular mortality from Q1 to Q5 were assessed by linear regression. Patients with LVEF < 50% had a progressive decrease in the rates of all-cause and cardiovascular death at 1 year (12.1% in Q1 to 6.5% in Q5, p = 0.003; and 8.4% in Q1 to 3.8% in Q5, p = 0.007, respectively) and 3 years (30.5% in Q1 to 17.0% in Q5, p = 0.003; and 23.9% in Q1 to 9.8% in Q5, p = 0.003, respectively). These trends remained significant after adjusting for clinical characteristics and risk. No significant trend in mortality was observed in patients with LVEF ≥ 50%. In a cohort of real-life ambulatory patients with HF, mortality progressively declined in patients with LVEF < 50%, but the same trend was not observed in patients with preserved LVEF.
- Subjects
HEART disease related mortality; HEART failure; CARDIOVASCULAR disease related mortality; VENTRICULAR ejection fraction; LEFT heart ventricle diseases
- Publication
Scientific Reports, 2021, Vol 11, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-79926-3