We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Nonalcoholic fatty liver disease vs. obesity on the risk of erosive oesophagitis.
- Authors
Hung, Wei‐Chieh; Wu, Jin‐Shang; Yang, Yi‐Ching; Sun, Zih‐Jie; Lu, Feng‐Hwa; Chang, Chih‐Jen
- Abstract
Background Erosive oesophagitis ( EE) may be complicated by oesophageal ulcers, peptic stricture, Barrett's oesophagus and oesophageal adenocarcinoma. There have been few studies examining the influence of nonalcoholic fatty liver disease ( NAFLD) on EE, and even fewer exploring the simultaneous effects of NAFLD, general and central obesity on EE. We thus aim to clarify the relationship between NAFLD and EE when general and/or central obesity are considered simultaneously. Materials and methods In this cross-sectional study, we enrolled 12 090 subjects who underwent a health check-up at the Health Examination Center of a university hospital between January 2000 and August 2009 for analysis. NAFLD was diagnosed using liver ultrasound and EE was defined according to the Los Angeles classification by oesophagogastroduodenoscopy. Results Subjects with EE (1922; 15·9%) had a higher proportion of NAFLD, general and central obesity. With adjustment for age, gender, hypertension, diabetes mellitus, hiatal hernia, hypertriglyceridemia, high-density lipoprotein cholesterol, alcohol consumption, tea drinking, smoking and habitual exercise, the results of the multivariate analyses showed that general obesity, central obesity and NAFLD were all significantly associated with EE in their separate models. When considering general obesity, central obesity and NAFLD simultaneously, NAFLD, but neither general nor central obesity, remained positively correlated to EE. In addition, male gender, hiatal hernia and hypertriglyceridemia were all significantly associated with EE. Conclusion In addition to general and central obesity, NAFLD is independently associated with increased risk of EE, and the detrimental effect of NAFLD on EE might be greater than those of general and central obesity.
- Subjects
FATTY liver; LIVER diseases; PREVENTION of obesity; ESOPHAGEAL perforation; DUODENOSCOPY
- Publication
European Journal of Clinical Investigation, 2014, Vol 44, Issue 12, p1143
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.12348