We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
N-terminal pro-brain natriuretic peptide used for the prediction of coronary artery stenosis.
- Authors
Wolber, T.; Maeder, M.; Rickli, H.; Riesen, W.; Binggeli, C.; Duru, F.; Ammann, P.
- Abstract
Background The level of the inactive N-terminal fragment of pro-brain (B-type) natriuretic peptide (NT-proBNP) is a prognostic marker in patients with acute and chronic coronary artery disease (CAD). It might also be valuable for non-invasive diagnosis of coronary artery disease. Materials and methods The NT-proBNP was measured in 781 consecutive patients with normal left ventricular function referred for coronary angiography owing to symptoms or signs of CAD. The diagnostic value of NT-proBNP was assessed for predicting CAD at angiography. Results Elevated NT-proBNP levels were associated with the extent of CAD and with the female sex ( P < 0·001). The ability of NT-proBNP to predict significant coronary disease at angiography was assessed separately for men using a cut-off point of 85 pg mL−1, positive likelihood ratio 2·2 (95% CI, 1·7–3·0), negative likelihood ratio 0·53 (95% CI 0·45–0·63) and area under the receiver-operating-characteristic (ROC) curve 0·72: for women, it was assessed using a cut-off point of 165 pg mL−1, positive likelihood ratio 2·4 (95% CI, 1·7–3·4), negative likelihood ratio 0·55 (95% CI, 0·44–0·70) and area under ROC curve 0·71. In multiple logistic-regression analysis, NT-proBNP added significant independent predictive power to other clinical variables in models predicting CAD (odds ratio 2·76, 95% CI, 1·76–4·32, P < 0·001). Conclusions The NT-proBNP is a marker of non-obstructive CAD and of significant coronary stenosis. In conjunction with other clinical information, measurement of NT-proBNP with the use of sex-specific reference ranges may improve the non-invasive prediction of CAD.
- Subjects
ATRIAL natriuretic peptides; BIOMARKERS; CORONARY artery stenosis; CORONARY circulation; REFERENCE values; ANGIOCARDIOGRAPHY; BIOCHEMISTRY
- Publication
European Journal of Clinical Investigation, 2007, Vol 37, Issue 1, p18
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/j.1365-2362.2007.01731.x