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- Title
Lower Urinary Tract Function After Intra-arterial Chemotherapy with Concurrent Pelvic Radiotherapy for Invasive Bladder Cancer.
- Authors
Sekido, Noritoshi; Miyanaga, Naoto; Kikuchi, Koji; Takeshima, Hitoshi; Akaza, Hideyuki
- Abstract
Background: Intra-arterial chemotherapy with concurrent pelvic radiotherapy as a bladder-sparing regimen for invasive bladder cancer is highly promising for selected patients. However, lower urinary tract function after this treatment has not been fully investigated.Methods: The urodynamic effects of intra-arterial chemothrapy with concurrent pelvic radiotherapy were retrospectively evaluated in 14 patients with organ-confined invasive bladder cancer. The post-treatment urodynamic findings were compared with the pretreatment ones (n = 7), and a comparison was made between the serial urodynamic findings after the treatment in another seven patients who were able to undergo the pretreatment urodynamic study (UDS).Results: The median follow-up period up to the latest UDS was 34 months. Of the 14 patients, the latest UDS revealed some storage dysfunctions in 11 (79%) and some emptying dysfunctions in three (23%). Uninhibited detrusor contraction and decreased bladder compliance were recorded in 29 and 43% at the pretreatment UDS and approximately 50–60 and 20–60% in the serial follow-up studies, respectively (n = 7). Impaired detrusor contractility lasted in one patient. In the seven patients without the pretreatment UDS, decreased maximum cystometric capacity and decreased compliance were recorded in approximately 50–60 and 20–60% at the serial UDS, respectively. Detrusor contractility was aggravated in one patient and completely lost in one with time.Conclusions: The urodynamic findings indicate that the bladder-sparing regimen might result in perpetuating the lower urinary tract dysfunctions due to invasive bladder cancer itself and/or transurethral surgery and might injure the infrasacral autonomic nerves and the bladder itself.
- Publication
Japanese Journal of Clinical Oncology, 1999, Vol 29, Issue 10, p479
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/29.10.479