We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
How to Diagnose and Treat a Cancer of Unknown Primary Site.
- Authors
Tomuleasa, Ciprian; Zaharie, Florin; Muresan, Mihai-Stefan; Pop, Laura; Fekete, Zsolt; Dima, Delia; Frinc, Ioana; Trifa, Adrian; Berce, Cristian; Jurj, Ancuta; Berindan-Neagoe, Ioana; Zdrenghea, Mihnea; Ciuleanu, Tudor-Eliade
- Abstract
Almost one in every three patients with advanced tumors have distant metastasis at the time of clinical diagnosis. In most cases, the primary tumor site is identified immediately, within a few days. But for some patients, the primary lesion cannot be found after the initial clinical assessment. These cases are called cancers of unknown primary origin (CUPs), a clinical diagnosis very difficult to manage by physicians due to the absence of a standard-of-care for the initial therapeutic regimen, as well as due to the impossibility to include these cases in randomized clinical trials. A cancer of unknown primary site is often associated with a poor prognosis as patients are usually treated with a non-selective empirical therapy. In the current paper, we summarize both the diagnostic challenges for patients with a cancer of unknown primary site as well as the current available therapeutic options, with emphasis on the management of this unique disease entity.
- Subjects
CANCER diagnosis; METASTASIS; CANCER treatment; PATIENT management; MEDICAL quality control
- Publication
Journal of Gastrointestinal & Liver Diseases, 2017, Vol 26, Issue 1, p69
- ISSN
1841-8724
- Publication type
Article
- DOI
10.15403/jgld.2014.1121.261.haz