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- Title
Tacrolimus May Induce the Production of Nucleolar Anti- nuclear Antibody in Liver Transplant Patients.
- Authors
Yongkang Wu; Bei Cai; Jiangtao Tang; Yangjuan Bai; Lanlan Wang
- Abstract
Background & Aims: Immunosuppressive drugs have been used to prevent graft rejection in most aflo-liver recipients and the immune state of these patients differs greatly before and after transplant operation. This study aims at evaluating the immune state of liver transplant patients treated with tacrolimus by investigating the production of anti-nuclear antibodies (ANA). Methods: A hundred and eighty-eight serum samples from 94 allo-liver recipients treated with tacrolimus and from 94 patients with matched liver diseases were tested for ANA by indirect immunofluorescence assay with HEp-2 cells as substrate. Results: ANA were detected as positive in 20.2% of the liver transplant patients treated with tacrolimus, and in 12.8% of disease-matched control patients, but this difference was not statistically significant (P=0.17). However, the frequency of nucleolarANA pattern in ANA-positive cases was significantly higher in the liver transplant patients (63.2%) than in the control group (16.7%) (P=0.0l). Conclusion: Tacrolimus may contribute to producing nucleolarANA in liver transplant patients. The autoimmune disease susceptibility of allo-liver recipients treated with tacrolimus requires further studying.
- Subjects
TACROLIMUS; LIVER transplantation; IMMUNOSUPPRESSIVE agents; GRAFT rejection prevention; AUTOIMMUNE diseases; IMMUNOFLUORESCENCE; PATIENTS
- Publication
Journal of Gastrointestinal & Liver Diseases, 2011, Vol 20, Issue 3, p267
- ISSN
1841-8724
- Publication type
Article