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- Title
GABA, Resting-State Connectivity and the Developing Brain.
- Authors
Kwon, Soo Hyun; Scheinost, Dustin; Lacadie, Cheryl; Benjamin, Jennifer; Myers, Eliza H.; Qiu, Maolin; Schneider, Karen C.; Rothman, Douglas L.; Constable, R. Todd; Ment, Laura R.
- Abstract
Background: Preclinical data demonstrate that gamma-aminobutyric acid (GABA) interneurons initiate connectivity in the developing brain. Objectives: The goal of this study was to compare GABA concentration and its relationship to functional connectivity in the brains of term and preterm infants at term-equivalent age. Methods: Infants received both magnetic resonance spectroscopy (MRS) and functional magnetic resonance imaging (fMRI) scans at term-equivalent age. Whole brain functional connectivity MRI data using intrinsic connectivity distribution maps were compared to identify areas with differences in resting-state functional connectivity between the preterm and term control groups. MRS measured concentrations of GABA, glutamate, N-acetyl-aspartate (NAA) and choline; NAA/choline was then calculated for comparison between the 2 groups. Results: Preterm infants had lower right frontal GABA and glutamate concentrations than term controls and showed a significantly different relationship between connectivity and GABA concentration in the right frontal lobe. Preterm infants had a positive correlation between GABA concentration and connectivity, while term controls demonstrated a negative correlation between these two developmentally regulated parameters. Conclusion: These results suggest that regional GABA concentrations are associated with normal and altered neonatal resting-state connectivity. © 2014 S. Karger AG, Basel
- Subjects
GABA; NEURAL development; NUCLEAR magnetic resonance spectroscopy; FUNCTIONAL magnetic resonance imaging; PREMATURE infants
- Publication
Neonatology (16617800), 2014, Vol 106, Issue 2, p149
- ISSN
1661-7800
- Publication type
Article
- DOI
10.1159/000362433