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- Title
Synthesis, Characterisation and Antiproliferative Studies of Allyl(dicarbonyl)(cyclopentadienyl)molybdenum Complexes and Cyclodextrin Inclusion Compounds.
- Authors
Braga, Susana S.; Mokal, Vijaya; Paz, Filipe A. Almeida; Pillinger, Martyn; Branco, Ana F.; Sardão, Vilma A.; Diogo, Cátia V.; Oliveira, Paulo J.; Marques, Maria P. M.; Romão, Carlos C.; Gonçalves, Isabel S.
- Abstract
The complexes [(η5-C5H4-CO-R)Mo(CO)2(η3-C3H5)] [R = OH ( 1), Phe-OMe ( 2)] have been examined as guests for the cyclodextrin (CD) hosts β-CD and heptakis(2,3,6-tri- O-methyl)-β-CD (TRIMEB), and the resultant inclusion compounds have been characterised in the solid state by elemental and thermogravimetric analyses, powder X-ray diffraction, 13C{1H} cross-polarisation (CP) magic angle spinning (MAS) NMR spectroscopy and FTIR spectroscopy. Single-crystal X-ray analysis of 1 shows that the unit cell contains centrosymmetric supramolecular dimers comprising two dicarbonyl complexes linked through hydrogen-bonding interactions involving the carboxylic acid groups. In screening tests for antiproliferative effects, the CD adducts containing 1 displayed enhanced antitumour activity against mouse melanoma (when compared with nonincluded 1), while showing minimal activity towards human adenocarcinoma and nontumour rat myoblast cell lines. TRIMEB encapsulation resulted in a predominant toxic effect on tumour cells versus the non-neoplastic myoblast cells.
- Subjects
MOLYBDENUM compounds synthesis; CYCLODEXTRINS; INCLUSION compounds; CARBOXYLIC acids; MELANOMA
- Publication
European Journal of Inorganic Chemistry, 2014, Vol 2014, Issue 29, p5034
- ISSN
1434-1948
- Publication type
Article
- DOI
10.1002/ejic.201402540