We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Oncolytic virotherapy.
- Authors
Russell, Stephen J; Peng, Kah-Whye; Bell, John C
- Abstract
Oncolytic virotherapy is an emerging treatment modality that uses replication-competent viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a single-shot virotherapy cure, identification of drugs that accelerate intratumoral virus propagation, strategies to maximize the immunotherapeutic action of oncolytic viruses and clinical confirmation of a critical viremic threshold for vascular delivery and intratumoral virus replication. The primary clinical milestone has been completion of accrual in a phase 3 trial of intratumoral herpes simplex virus therapy using talimogene laherparepvec for metastatic melanoma. Key challenges for the field are to select 'winners' from a burgeoning number of oncolytic platforms and engineered derivatives, to transiently suppress but then unleash the power of the immune system to maximize both virus spread and anticancer immunity, to develop more meaningful preclinical virotherapy models and to manufacture viruses with orders-of-magnitude higher yields than is currently possible.
- Subjects
CANCER treatment; VIROTHERAPY; VIRAL replication; IMMUNOTHERAPY; HERPES simplex virus; MELANOMA treatment
- Publication
Nature Biotechnology, 2012, Vol 30, Issue 7, p658
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt.2287