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- Title
Synthesis and In Vitro cytotoxicity of Cis-[Pt(NH<sub>3</sub>)(NH<sub>2</sub>OH)Cl<sub>2</sub>].
- Authors
Ye, Qing-Song; Liu, Wei-Ping; Chen, Xi-Zhu; Yu, Yao; Chang, Qiao-Wen; Hou, Shu-Qian
- Abstract
A novel mixed NH3/NH2OH platinum(II) complex cis-[Pt(NH3)(NH2OH)Cl2] was synthesized and characterized by elemental analysis, FAB-MS, FT-IR and 1H NMR spectroscopy. This complex was determined to have a good water-solubility and satisfactory stability. The pertinent complex was evaluated for its in vitro cytotoxicity against 3AO, HCT-116, LNcap, A549/ATCC and SGC-7901 human carcinoma cell lines. It shows appreciable cytotoxic activity that is comparable with cisplatin and is much more active than carboplatin.
- Publication
Archives of Pharmacal Research, 2010, Vol 33, Issue 6, p807
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-010-0602-x