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- Title
Intracerebroventricular gisenosides are antinociceptive in proinflammatory cytokine-induced pain behaviors of mice.
- Authors
Seo, Young-Jun; Kwon, Min-Soo; Choi, Hee-Woo; Jang, Jeong-Eun; Lee, Jin-Koo; Sun, Yuanjie; Jung, Jun-Sub; Park, Soo-Hyun; Suh, Hong-Won
- Abstract
Several ginsenoside (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1 and Rg3) are neuroprotective and antinociceptive agents. In this study, we assessed the effects of these ginsenosides following intracerebroventricular (i.c.v.) administration on the nociceptive behaviors induced by intrathecal injection of pro-inflammatory cytokines (tumor necrosis factor-a (TNF-α), interleukin-1β (IL-1β), and interferon-γ (IFN-γ)). The ginsenosides, Rb1, Rb2, Rc, Rd, Re, Rf and Rg1, significantly attenuated the nociceptive behavior induced by TNF-α, IL-1β, and IFN-γ injection, but ginsenoside-Rg3 did not. These results suggest that several ginsenosides may regulate the nociceptive processing induced by pro-inflammatory cytokines.
- Publication
Archives of Pharmacal Research, 2008, Vol 31, Issue 3, p364
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-001-1165-x