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- Title
Intestinal type adenocarcinoma of the ethmoid: Outcomes of a treatment regimen based on endoscopic surgery with or without radiotherapy.
- Authors
Nicolai, Piero; Schreiber, Alberto; Bolzoni Villaret, Andrea; Lombardi, Davide; Morassi, Laura; Raffetti, Elena; Donato, Francesco; Battaglia, Paolo; Turri–Zanoni, Mario; Bignami, Maurizio; Castelnuovo, Paolo
- Abstract
Background The purpose of this study was to assess survival, prognostic factors, and complications in a cohort of patients with intestinal-type adenocarcinoma (ITAC) treated with transnasal endoscopic surgery ± radiotherapy (RT). Methods Patients with ITAC who underwent endoscopic surgery ± RT at 2 tertiary centers were retrospectively reviewed. Overall survival (OS) and event-free survival were calculated, and statistically significant variables were entered in a multivariate Cox regression model. Complications were also analyzed. Results One hundred-sixty-nine patients were included. Major complications occurred in 9.5% of patients. Adjuvant RT was delivered in 58.6% of patients. Five-year OS and event-free survival were 68.9% and 63.6%, respectively. Advanced pT classification, high-grade, and positive surgical margins were independently predictive of poor survival. Conclusion Endoscopic surgery ± RT is a valid treatment option in most cases of ITAC. When compared with series based on external surgery, our results support a definitive paradigm shift in the management of ITAC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E996-E1003, 2016
- Subjects
HEAD &; neck cancer treatment; ADENOCARCINOMA; CANCER treatment; ENDOSCOPIC surgery; CANCER radiotherapy research; CANCER prognosis
- Publication
Head & Neck, 2016, Vol 38, pE996
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24144