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- Title
High-dose-rate brachytherapy plus neck dissection for nodal disease.
- Authors
Beitler, Jonathan J.; Garg, Madhur; Owen, Randall P.; Sarta, Catherine; Smith, Richard V.; Yaparpalvi, Ravindra
- Abstract
Background Regional control for advanced nodal disease has been only marginally affected by concurrent chemoradiation, hyperfractionation, concomitant boost, or accelerated external radiation. Methods Twenty-five necks in 24 patients received brachytherapy treatment (20 Gy in 10 twice-daily fractions) in addition to external radiation, neck dissection ± chemotherapy. Indications for brachytherapy included initial treatment of bulky disease (n = 12), recurrence of neck disease in a previously treated patient with at least a 3-month disease-free interval (n = 6), persistent disease after a curative efforts (n = 4), inadequate external radiation (ie, <40 Gy) due to either intolerance or noncompliance (n = 3). Results Overall actuarial regional control was 67% at 2 years. Regional control for those receiving brachytherapy as part of their initial treatment was 82% despite a mean nodal diameter of 8.7 cm (range, 5–15 cm). The 2-year actuarial regional control was 56% for the patients with a disease-free interval of at least 3 years. Conclusion High-dose-rate brachytherapy produced excellent regional control. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
- Subjects
RADIOISOTOPE brachytherapy; NECK diseases; DRUG therapy; LYMPH nodes; THERAPEUTICS
- Publication
Head & Neck, 2008, Vol 30, Issue 7, p933
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.20799