We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Increased salivary AKR1B10 level: Association with progression and poor prognosis of oral squamous cell carcinoma.
- Authors
Ko, Hui‐Hsin; Peng, Hsin‐Hui; Cheng, Shih‐Jung; Kuo, Mark Yen‐Ping
- Abstract
Background: Aldo‐keto reductase family 1 member B10 (AKR1B10) expression in oral squamous cell carcinoma (OSCC) tissue specimens is correlated with the progression and prognosis of OSCC. Methods: Saliva samples were obtained from 35 normal controls and 86 patients with OSCC before cancer surgery. The AKR1B10 levels were determined using enzyme‐linked immunosorbent assay (ELISA). Results: The mean salivary AKR1B10 levels were significantly higher in the patients with OSCC than in the normal controls (P <.001). Higher salivary AKR1B10 levels were significantly associated with larger tumor size, more advanced clinical stage, and areca quid chewing habit. Patients with OSCC with a higher salivary AKR1B10 level (>646 pg/mL) had a significantly poorer survival than those with a lower (≤646 pg/mL) salivary AKR1B10 level (P =.026). Conclusion: The salivary AKR1B10 level may be a promising biomarker for screening high‐risk patients with OSCC and monitoring the progression of OSCC.
- Subjects
DISEASE progression; SQUAMOUS cell carcinoma; SALIVARY glands; CANCER cells; CELL proliferation
- Publication
Head & Neck, 2018, Vol 40, Issue 12, p2642
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25370