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- Title
Effects of octreotide therapy in progressive head and neck paragangliomas: Case series.
- Authors
Hulsteijn, Leonie T.; Duinen, Nicolette; Verbist, Berit M.; Jansen, Jeroen C.; Klaauw, Agatha A.; Smit, Jan W. A.; Corssmit, Eleonora P. M.; Andersen, Peter
- Abstract
Background Octreotide, a somatostatin analog, may be beneficial in the treatment of head and neck paragangliomas (HNPGLs). Methods We conducted a nonblinded, prospective intervention study. During 1 year, patients received a monthly intramuscular injection of 30 mg octreotide. Pretreatment and posttreatment tumor volumes were assessed by MRI, urinary catecholamine secretion was measured, and HNPGL-related signs and symptoms were recorded. Results In 1 of 4 included patients with HNPGL, a stabilization of tumor growth was observed after octreotide therapy. In 1 patient, octreotide therapy was discontinued before the end of the study because of potential side effects. No improvements in HNPGL-related signs and symptoms were observed. Conclusion In 1 of 4 patients, HNPGL tumor growth velocity was reduced after octreotide therapy. Research assessing the effects of somatostatin analogues targeting different somatostatin receptor subtypes or combined with other therapies may offer new possibilities for the treatment of HNPGLs. © 2013 Wiley Periodicals, Inc. Head Neck 35: E391-E396, 2013
- Subjects
OCTREOTIDE acetate; PARAGANGLIOMA; NECK tumors; HEAD tumors; CATECHOLAMINES; TUMOR growth; THERAPEUTICS
- Publication
Head & Neck, 2013, Vol 35, Issue 12, pE391
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23348