We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Growth inhibition of head and neck carcinomas by D-allose.
- Authors
Mitani, Tomoo; Hoshikawa, Hiroshi; Mori, Terushige; Hosokawa, Tomohiro; Tsukamoto, Ikuko; Yamaguchi, Fuminori; Kamitori, Kazuyo; Tokuda, Masaaki; Mori, Nozomu
- Abstract
Background An inhibitory effect of D-allose, a rare sugar, on several cancer cell lines has been reported. This study aimed to investigate the growth inhibition of head and neck squamous cell carcinoma cells by D-allose. Methods We treated 3 head and neck carcinoma cell lines with D-allose, D-fructose, D-psicose, and D-glucose. Cell growth assays as well as analyses of messenger RNA (mRNA) expression, cell cycle, apoptosis, and uptake of 14C-glucose were performed. Results D-allose had inhibitory effects on all 3 cell lines and tended to upregulate mRNA expression of glucose transporters, p21 and p53, and downregulate mRNA expression of cyclin A2, cyclin B1, and CDC2. We observed that D-allose tended to interfere with the intracellular uptake of D-glucose and induced apoptosis. Conclusion Our results indicate that D-allose inhibits the growth of head and neck squamous cell carcinoma cells. D-allose has a considerable potential as a new anticancer agent in those patients. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
- Subjects
SQUAMOUS cell carcinoma; HEAD &; neck cancer; CANCER cells; CELL lines; CELL cycle; GLUCOSE; MESSENGER RNA
- Publication
Head & Neck, 2009, Vol 31, Issue 8, p1049
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21070