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- Title
Involvement of Dietary Fatty Acids in Multiple Biological and Psychological Functions, in Morbidly Obese Subjects.
- Authors
Chalut-Carpentier, Anne; Pataky, Zoltan; Golay, Alain; Bobbioni-Harsch, Elisabetta
- Abstract
Background: Fatty acid (FA) profile is often altered, in morbidly obese subjects, both before and after bariatric surgery. We measured FA plasma levels before and 6 months after Roux-en-Y gastric bypass (RYGB), in order to evaluate their relationship with different biological and psychological parameters and the impact of RYGB on the FA plasma levels. Methods: Thirty eight morbidly obese patients were investigated before RYGB, and 28 of them were reexamined 6 months postoperatively. Anxiety, depression, and quality of life were evaluated by validated questionnaires. Plasma FA (saturated, monounsaturated, polyunsaturated ω-6 and ω-3), vitamins A and E, fasting insulinemia, and high-sensitive C-reactive protein (hs-CRP) were measured. Results: Before surgery, ω-3 polyunsaturated FA and vit A showed significant negative relationship with fasting insulinemia (γ-linolenic p = 0.03, eicosapentaenoic, vit A p = 0.01) and hs-CRP (eicosapentaenoic p = 0.03, vit A p = 0.02) and a positive link with HDL cholesterol (γ-linolenic p = 0.03, vit A p = 0.02). Depression score was significantly and negatively linked with palmitoleic ( p = 0.03), γ-linolenic ( p = 0.006), dihomo-γ-linolenic ( p = 0.02), and α-linolenic ( p = 0.03) acids. After surgery, FA and both vit A and E were significantly reduced. Vit A levels were below 2.4 μmol/l in 63 % of the patients, preoperatively, and in 79 % after surgery. Preoperative levels of linoleic acid were significantly related with the postoperative weight reduction ( p = 0.0006). Conclusions: FA are involved in several biological and psychological functions. The RYGB-induced reduction of FA could have deleterious consequences on vitamin absorption, metabolism, and depression. Thus, the surveillance of FA levels is of primary importance both before and after RYGB.
- Subjects
MORBID obesity; DIETARY fats; BARIATRIC surgery; PATIENTS; QUALITY of life; GAMMA-linolenic acid; C-reactive protein; MENTAL health
- Publication
Obesity Surgery, 2015, Vol 25, Issue 6, p1031
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-014-1471-z