We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The effect of different analytical platforms and methods on the performance of population-specific adjusted calcium equation.
- Authors
Jassam, N; Narayanan, D; Turnock, D; Lee, G; Earp, K; West, J; Day, A; Jeffery, J; Zouwail, S; El-Farhan, N; Dearman, R; Hayden, K; Osborne, J; Willett, S; Barth, JH; Barth, J H
- Abstract
<bold>Background: </bold>A recent attempt to improve the diagnostic value of adjusted calcium addressed a primary care-specific adjusted calcium equation, but validated the new equation for Roche Cobas, BCG and NM-BAPTA methods only. In this study, we aim to validate a population-specific equation for other methods and platforms.<bold>Method: </bold>We collected retrospective patient data-sets from 15 hospital laboratories using a range of commercially available analytical platforms and methods for calcium and albumin measurements. Raw data-sets were collected and filtered according to Payne's criteria, and separate adjusted calcium equations were derived for hospitalized and primary care patients.<bold>Results: </bold>Mean albumin and calcium results were significantly higher in primary care populations (P < 0.0001). The prevalence of hypocalcaemia using adjusted calcium ranged between 6% and 44% for inpatient data-sets and was higher in users of BCG methods. The application of community-specific adjustment equation to primary care data-sets reduced the prevalence of hypocalcaemia (mean 1.7%, range 0.8-3.7%).<bold>Conclusion: </bold>We demonstrated that the use of a community-specific calcium adjustment equation to a primary care population reduces both the percentage and the variation of hypocalcaemia between different laboratories.
- Subjects
EQUATIONS; CALCIUM in the body; ALBUMINS; DIAGNOSIS; PRIMARY care; HOSPITAL care; RETROSPECTIVE studies; HYPOCALCEMIA; CALCIUM; ALGORITHMS
- Publication
Annals of Clinical Biochemistry, 2020, Vol 57, Issue 4, p300
- ISSN
0004-5632
- Publication type
journal article
- DOI
10.1177/0004563220931876