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- Title
Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels.
- Authors
Salles, Fernanda; Bacellar, Andrea; Amorim, Mirla; Orge, Glória; Sundberg, Michael; Lima, Márcia; Santos, Silvane; Porto, Aurélia; Carvalho, Edgar
- Abstract
Background Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection. Results Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis. Conclusion These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.
- Subjects
T cells; STRONGYLOIDIASIS; LEUKEMIA; HTLV diseases; ANTHELMINTICS; IMMUNE response; INTERLEUKIN-2; DISEASES
- Publication
Transactions of the Royal Society of Tropical Medicine & Hygiene, 2013, Vol 107, Issue 8, p526
- ISSN
0035-9203
- Publication type
Article
- DOI
10.1093/trstmh/trt052