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- Title
Could Cesarean Delivery Help Prevent Mother-to-Child Transmission of Human T-Lymphotropic Virus Type 1?
- Authors
Prates, Gabriela; Paiva, Arthur; Haziot, Michel E; Fonseca, Luiz Augusto M; Smid, Jerusa; Marcusso, Rosa Maria do N; Assone, Tatiane; Oliveira, Augusto C P de; Casseb, Jorge
- Abstract
Background Mother-to-child transmission (MTCT) of human T-lymphotropic virus type 1 (HTLV-1) is an important route of transmission that can cause lifelong infection. There is high morbidity and mortality due to adult T-cell leukemia/lymphoma, HTLV-1–associated myelopathy (HAM), and other inflammatory disorders. These conditions develop in nearly 10% of people with HTLV-1 infection, with a higher risk if infection occurs early in life. Identification of risk factors can inform targeted measures to reduce HTLV-1 MTCT. This study aimed to investigate the potential of cesarean delivery to prevent HTLV-1 MTCT. Methods We performed a review of the cases of women and their offspring under regular follow-up at the HTLV-1 outpatient clinic at the Institute of Infectious Diseases Emilio Ribas. Results A total of 177 HTLV-1–infected women and 369 adult offspring were investigated. Overall, 15% of the children were positive for HTLV-1 and 85% were negative. Regarding vertical transmission, we found that a breastfeeding duration of >6 months was associated with MTCT. Moreover, maternal proviral load was not associated with transmission, but high educational level and cesarean delivery were identified as protective factors. Conclusions HTLV-1 MTCT was associated with mother's age at delivery of >25 years, low educational level, prolonged breastfeeding, and vaginal delivery.
- Subjects
HTLV-I; CESAREAN section; DELIVERY (Obstetrics); ADULT T-cell leukemia; ADULT children
- Publication
Journal of Infectious Diseases, 2023, Vol 228, Issue 12, p1766
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad219