We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Atopic eczema: role of microorganisms on the skin surface.
- Authors
Ring, J.; Abeck, D.; Neuber, K.
- Abstract
The pathophysiology of atopic eczema (AE) is still poorly understood. One possible concept favors IgE-mediated reactivity towards allergens that enter the skin from the outside or through the blood. Microorganisms of the cutaneous flora also might represent a stimulus for allergic skin reactions. Abnormal bacterial skin colonization is a characteristic feature of AE. <em>Staphylococcus aureus</em> (<em>S. aureus</em>) is the most common pathogen. Binding to host cells involves special receptors, such as fibronectin or laminin. Specific IgE antibodies to <em>S. aureus</em> can be detected in the blood. Whereas the clinical relevance of anti-staphylococcal antibodies is still controversial, specific IgE antibodies to <em>Pityrosporum</em> species as well as positive type I prick test reactions to these yeasts seem to correlate with the intensity of eczematous lesions in the head and neck regions of patients with AE. Both antimicrobial and antifungal treatment has been shown helpful in some cases of AE.
- Subjects
ATOPIC dermatitis; ECZEMA; SKIN inflammation; MICROORGANISMS; STAPHYLOCOCCUS aureus; MALASSEZIA ovale
- Publication
Allergy, 1992, Vol 47, Issue 4, p265
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/j.1398-9995.1992.tb02051.x