We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hypofibrinolytic Activity after Total Joint Replacement.
- Authors
Kikuchi, H.; Tanaka, S.; Nakagiri, Y.; Yamane, T.; Fujiwara, S.; Katsuhisa, K.; Tan, A.; Matsuo, O.
- Abstract
Tissue-type plasminogen activator (t-PA), tissue-type plasminogen activator inhibitor (t-PAI), and other factors (platelets, fibrinogen, fibrinogen degradation products, antithrombin-III, plasminogen, and α2-plasmin inhibitor [α2-PI]) related to the fibrinolytic system were studied in 21 patients undergoing total joint replacement. Seventeen of the 21 patients revealed an impaired fibrinolytic activity from the first to seventh postoperative day and a subsequent return to the preoperative level by the fourteenth postoperative day. There were accompanying increases in the level of α2-PI and in the t-PAI/t-PA ratio, and there was decrease in plasminogen level. Such hypofibrinolytic states may be related to a higher incidence of postoperative thrombosis in total joint replacement patients.
- Subjects
FIBRINOLYSIS; ARTIFICIAL joints; PLASMIN; PLASMINOGEN; FIBRINOGEN; ANTITHROMBIN III
- Publication
Vascular Surgery, 1992, Vol 26, Issue 1, p59
- ISSN
0042-2835
- Publication type
Article
- DOI
10.1177/153857449202600110