We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder.
- Authors
Womersley, Jacqueline S.; Mpeta, Bafokeng; Dimatelis, Jacqueline J.; Kellaway, Lauriston A.; Stein, Dan J.; Russell, Vivienne A.
- Abstract
Background: Developmental stress has been hypothesised to interact with genetic predisposition to increase the risk of developing substance use disorders. Here we have investigated the effects of maternal separation-induced developmental stress using a behavioural proxy of methamphetamine preference in an animal model of attention-deficit/hyperactivity disorder, the spontaneously hypertensive rat, versus Wistar Kyoto and Sprague-Dawley comparator strains. Results: Analysis of results obtained using a conditioned place preference paradigm revealed a significant strain × stress interaction with maternal separation inducing preference for the methamphetamine-associated compartment in spontaneously hypertensive rats. Maternal separation increased behavioural sensitization to the locomotor- stimulatory effects of methamphetamine in both spontaneously hypertensive and Sprague-Dawley strains but not in Wistar Kyoto rats. Conclusions: Our findings indicate that developmental stress in a genetic rat model of attention-deficit/hyperactivity disorder may foster a vulnerability to the development of substance use disorders.
- Subjects
PSYCHOLOGICAL stress; PHYSIOLOGICAL effects of methamphetamine; ATTENTION-deficit hyperactivity disorder; SUBSTANCE-induced disorders; LABORATORY rats; DIATHESIS-stress model (Psychology); MATERNAL deprivation in animals
- Publication
Behavioral & Brain Functions, 2016, Vol 12, p1
- ISSN
1744-9081
- Publication type
Article
- DOI
10.1186/s12993-016-0102-3