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- Title
Acceptability and effect of TiF<sub>4</sub> on dental caries: a randomized controlled clinical trial.
- Authors
de Souza, Beatriz Martines; de Souza SILVA, Mayara; BRAGA, Aline Silva; dos SANTOS, Daiana Moreli Soares; de Souza CARVALHO, Thamyris; dos SANTOS, Natália Mello; RIOS, Daniela; BUZALAF, Marilia Afonso Rabelo; MAGALHÃES, Ana Carolina
- Abstract
This randomized three-armed controlled clinical trial compared the effect of titanium tetrafluoride (TiF4) and sodium fluoride (NaF) varnishes on caries control in smooth surfaces of permanent dentition and children's acceptability. Sixty children (6-8 y/o) were randomly divided into TiF4 (2.45% F-), NaF (2.26% F-) or placebo (control) groups. Varnishes were applied on permanent teeth once a week for the first 4 weeks and after the 6th and 12th months of the study. The variables were as follows: International Caries Detection and Assessment System (ICDAS) scores, quantitative fluorescence changes, visual plaque index (VPI) and degree of acceptability. Two-way RM-ANOVA, ANOVA/Tukey and χ2 tests were performed (p < 0.05). No differences were found between the treatments with respect to ICDAS scores (p = 0.32). O nly TiF4 reduced the mean fluorescence loss significantly at 18 months compared to the baseline (p = 0.003). TiF4 showed a lower percentage of new caries lesions by tooth surface than the placebo, while NaF did not induce such a change (p < 0.014). Regardless of the treatment, more than 95% of the participants reported being satisfied. For all groups, the VPI decreased significantly at 3 months compared to the baseline value (p < 0.001), with no differences between the treatments (p = 0.17). TiF4 had a similar ability to control caries lesions as NaF; however, only TiF4 differed from the placebo (p = 0.004). The acceptability of TiF4 varnish was similar to that of NaF varnish.
- Subjects
RANDOMIZED controlled trials; DENTAL caries; CLINICAL trials; VARNISH &; varnishing; SODIUM fluoride
- Publication
Brazilian Oral Research, 2021, Vol 35, p1
- ISSN
1806-8324
- Publication type
Article
- DOI
10.1590/1807-3107bor-2021.vol35.0121