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- Title
Asymmetric Dimethylarginine and Endothelial Progenitor Cells After Renal Transplantation: the Effect of Exercise Training.
- Authors
TEPLAN, V.; LESNÁ, I. KRÁLOVÁ; PITHA, J.; MAHROVÁ, A.; RACEK, J.; VALKOVSKY, I.; SEKERKOVÁ, A.; STOLLOVÁ, M.
- Abstract
Level of asymmetric dimethylarginine (ADMA) is elevated and endothelial progenitor cells (EPC) and stem cells (SC) are decreased in patients undergoing renal transplantation (Tx) and may contribute to cardiovascular complications. We tested the hypothesis that ADMA, EPC and SC can be influenced with regular physical exercise early after Tx. Blood samples of ADMA, EPC, SC, adipocytokines and metabolic parameters were randomly obtained from 50 transplant patients before and 6 months after exercise program (Group I). Fifty age, sex, HLA typing, duration of dialysis and immunosupression regimenmatched non exercising transplant were examined as controls (Group II). After 6 months, in Group I ADMA decreased (3.50±0.45 vs 2.11±0.35 pmol/l, P<0.01) and was lower comparing to Group II (P<0.01), SC and EPC also decreased (2816±600 vs 2071±480 cells/ml resp. 194±87 to 125±67 cells/ml, P<0.02). Next changes in Group I: adlponectin (PcO.Ol), leptin (PcO.Ol), resistin (P<0.02). Visfatin, blood lipids, HbAlc, insulin and blood pressure were also influenced by training program (P<0.05).
- Subjects
KIDNEY transplantation; PHYSIOLOGICAL effects of arginine; ENDOTHELIAL cells; PROGENITOR cells; EXERCISE; ADIPOKINES
- Publication
Physiological Research, 2014, Vol 63, pS411
- ISSN
0862-8408
- Publication type
Article
- DOI
10.33549/physiolres.932886