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- Title
Synthesis and biological evaluation of some N-substituted indoles.
- Authors
Badiger, Jaishree; Manjulatha, K.; Girish, M.; Sharif, Adil; Purohit, M. G.
- Abstract
The esterification of 1-alkyl/aryl-3-ethoxy carbonyl-5-hydroxy-2-methyl indoles (1a-g) with ethyl chloroacetate and ethyl chloroformate, afforded ethyl 5-(ethoxycarbonyl) methoxy]-1-alkyl/aryl-2-methyl-indole-3-carboxylate (2a-g) and 3-(ethoxycarbonyl)-1-alkyl/aryl-2-methyl-1H-indol-5-yl ethyl carbonate (3a-g) respectively. The reaction of 1b-g with monochloroacetic acid and 2-chloropropionic acid afforded the corresponding indole acetic acid (4b-g) and propanoic acid (5b-g) derivatives respectively. These newly synthesized compounds were evaluated in vivo for potential anti-inflammatory and analgesic activities and the results were compared with indomethacin. These analogues were administered p.o. at a dose level of 20 mg/kg.
- Subjects
INDOLEACETIC acid; ESTERIFICATION; ETHOXYLATES; CARBONYL compounds; ETHYL chloride; NONSTEROIDAL anti-inflammatory agents; PROPIONIC acid; INDOMETHACIN; ANTIRHEUMATIC agents
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2009, p217
- ISSN
1551-7004
- Publication type
Article