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- Title
Association of Chr17q25 with cerebral white matter hyperintensities and cognitive impairment: the J- SHIPP study.
- Authors
Tabara, Y.; Igase, M.; Okada, Y.; Nagai, T.; Uetani, E.; Kido, T.; Ochi, N.; Takita, R.; Yamamoto, M.; Kohara, K.; Miki, T.
- Abstract
Background and purpose A recent genome-wide association study has successfully identified several genetic variations in the Chr17q25 locus as susceptible genotypes for white matter hyperintensities. We report the first replication study in subjects of non- European origin. We also investigated possible associations with other asymptomatic cerebrovascular diseases and cognitive function. Methods Study subjects were 1190 general Japanese persons (66.0 ± 8.9 years old). Asymptomatic cerebrovascular damage, including lacunar infarctions, microbleeds, periventricular hyperintensity and deep and subcortical white matter hyperintensity ( DSWMH), was evaluated by brain magnetic resonance imaging. Results A polymorphism rs3744028 was significantly associated with DSWMH grade ( P = 0.015) but not periventricular hyperintensity, lacunar infarction, and microbleeds. Although age, hypertension, insulin resistance, B-type natriuretic peptide, and carotid atherosclerosis were also correlated with DSWMH, association of the genotype was independent of these environmental risk factors. In contrast, the risk allele had a protective effect against reduced cognitive function. Conclusion Susceptibility of the 17q25 locus may be conserved beyond ethnic differences. Genetic variants may have bipolar effects on brain histological and functional changes.
- Subjects
MILD cognitive impairment; HUMAN genetic variation; CEREBROVASCULAR disease; COGNITIVE ability; INFARCTION; NATRIURETIC peptides; ATHEROSCLEROSIS
- Publication
European Journal of Neurology, 2013, Vol 20, Issue 5, p860
- ISSN
1351-5101
- Publication type
Article
- DOI
10.1111/j.1468-1331.2012.03879.x