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- Title
Real-time polymerase chain reaction in acute retinal necrosis following encephalitis.
- Authors
Rao, Vinita; Biswas, Jyotirmay; Lingam, Gopal
- Abstract
Acute retinal necrosis (ARN) following herpes simplex encephalitis (HSE) in an immunocompetent patient is a rare condition. Quantitative real-time polymerase chain reaction (qPCR) has made it possible to identify and quantify viral genome. We report a case of ARN following HSE managed with the help of qPCR. A 45-year-old man developed ARN following HSE and was treated with intravenous acyclovir and intravitreal foscarnet. The retinitis did not respond initially and the qPCR demonstrated a rise in the number of copies of the HSV-1 viral genome. With continued treatment with intravenous acyclovir and intravitreal ganciclovir, the retinitis healed and the qPCR confirmed a reduction in the viral load. qPCR has a high sensitivity and specificity for HSV and is a useful tool for diagnosis and treatment of viral retinitis.
- Subjects
RETINAL diseases; POLYMERASE chain reaction; ACYCLOVIR; VIRAL genetics; RETINAL disease diagnosis; DNA analysis; AQUEOUS humor; HERPESVIRUSES; VIRAL eye infections; DIAGNOSIS
- Publication
Indian Journal of Ophthalmology, 2018, Vol 66, Issue 2, p322
- ISSN
0301-4738
- Publication type
case study
- DOI
10.4103/ijo.IJO_748_17