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- Title
Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene.
- Authors
Nigel PS Crawford; Maurice R Eichenberger; Daniel W Colliver; Robert K Lewis; Gary A Cobbs; Robert E Petras; Susan Galandiuk
- Abstract
Background: Significant evidence suggests that a promoter polymorphism within the gene SLC11A1 is involved in susceptibility to both autoimmune and infectious disorders. The aim of this study was to evaluate whether SLC11A1 has a role in the susceptibility to inflammatory bowel disease (IBD) by characterizing a promoter polymorphism within the gene and two short tandem repeat (STR) markers in genetic proximity to SLC11A1. Methods: The studied population consisted of 484 Caucasians with IBD, 144 population controls, and 348 non-IBD-affected first-degree relatives of IBD patients. IBD subjects were re-categorized at the sub-disease phenotypic level to characterize possible SLC11A1 genotype-phenotype correlations. Polymorphic markers were amplified from germline DNA and typed using gel electrophoresis. Genotype-phenotype correlations were defined using case-control, haplotype, and family-based association studies. Results: This study did not provide compelling evidence for SLC11A1 disease association; most significantly, there was no apparent evidence of SLC11A1 promoter allele association in the studied Crohn's disease population. Conclusion: Our results therefore refute previous studies that have shown SLC11A1 promoter polymorphisms are involved in susceptibility to this form of IBD.
- Subjects
GENETIC polymorphisms; INFLAMMATORY bowel diseases; GENES; DNA; PHYSIOLOGY
- Publication
BMC Medical Genetics, 2005, Vol 6, p1
- ISSN
1471-2350
- Publication type
Article
- DOI
10.1186/1471-2350-6-10