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- Title
Wound degradomics - current status and future perspectives.
- Authors
Hermes, Olivia; Schlage, Pascal; dem Keller, Ulrich auf
- Abstract
Proteases are pivotal modulators of extracellular matrix components and bioactive proteins at all phases of cutaneous wound healing and thereby essentially contribute to the successful reestablishment of skin integrity upon injury. As a consequence, disturbance of proteolytic activity at the wound site is a major factor in the pathology of chronic wounds. A large body of data acquired in many years of research provide a good understanding of how individual proteases may influence the repair process. The next challenge will be to integrate these findings and to elucidate the complex interactions of proteolytic enzymes, their inhibitors and substrates on a system-wide level. Here, we present novel approaches that might help to achieve this ambitious goal in cutaneous wound healing research.
- Subjects
PROTEOLYTIC enzymes; EXTRACELLULAR matrix; BIOACTIVE compounds; ENZYME kinetics; SKIN injuries; PROTEOMICS; WOUND healing
- Publication
Biological Chemistry, 2011, Vol 392, Issue 11, p949
- ISSN
1431-6730
- Publication type
Article
- DOI
10.1515/BC.2011.092