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- Title
Nanometric Micelles with Photo-Triggered Cytotoxicity.
- Authors
Anilkumar, Parambath; Gravel, Edmond; Theodorou, Ioanna; Gombert, Karine; Thézé, Benoit; Ducongé, Frédéric; Doris, Eric
- Abstract
The development of a photo-responsive micellar system capable of triggering cell death is reported. Precursors of the micelles are synthesized by connecting a lipophilic chain to a hydrophilic polyethylene glycol via a photo-labile nitrobenzyl group. The resulting amphiphilic units are self-assembled in water forming 12 nm micelles that are readily internalized into cells. Upon photo-irradiation, micelles undergo cleavage and yield a cytotoxic nitrosobenzaldehyde derivative, which significantly inhibits the proliferation of MDA-MB-231 cells under standard in vitro conditions.
- Subjects
MICELLES synthesis; CELL death; HYDROPHILE-lipophile balance; NANOTECHNOLOGY; CELL-mediated cytotoxicity
- Publication
Advanced Functional Materials, 2014, Vol 24, Issue 33, p5246
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.201400840