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- Title
Reye's syndrome developing in an infant on treatment of Kawasaki syndrome.
- Authors
Chih-Ming Wei; Huey-Ling Chen; Ping-Ing Lee; Chong-Ming Chen; Chun-Yi Ma; Wuh-Liang Hwu
- Abstract
Aspirin is commonly used as an anti-inflammatory therapy for Kawasaki syndrome. Early initiation with high dose aspirin (80 to>100 mg/kg per day), followed by low-dose therapy at the afebrile stage, has been often used to reduce morbidity and mortality in coronary complications. We report a 10-month-old infant who was diagnosed with Kawasaki syndrome. Sudden onset of poor activity, poor appetite, lethargy, tachycardia, tachypnea, hepatomegaly, increased AST/ALT, coagulopathy and hyperammonemia developed 3 days after the high-dose aspirin therapy. His histopathological and ultrastructural findings from the liver biopsy were compatible with Reye's syndrome. He recovered completely, and there was no recurrence.
- Subjects
MUCOCUTANEOUS lymph node syndrome; REYE'S syndrome; ASPIRIN; INFANT diseases; PEDIATRICS; CHILDREN'S health
- Publication
Journal of Paediatrics & Child Health, 2005, Vol 41, Issue 5/6, p303
- ISSN
1034-4810
- Publication type
Article
- DOI
10.1111/j.1440-1754.2005.00617.x