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- Title
Rhenium and technetium tricarbonyl complexes of 1,4-Substituted pyridyl-1,2,3-triazole bidentate 'click' ligands conjugated to a targeting RGD peptide.
- Authors
Connell, Timothy U.; Hayne, David J.; Ackermann, Uwe; Tochon ‐ Danguy, Henri J.; White, Jonathan M.; Donnelly, Paul S.
- Abstract
New 1,4-substituted pyridyl-1,2,3-triazole ligands with pendent phenyl isothiocyanate functional groups linked to the heterocycle through a short methylene or longer polyethylene glycol spacers were prepared and conjugated to a peptide containing the arginine-glycine-aspartic acid peptide motif. Rhenium and technetium carbonyl complexes, [M(CO)3Lx(py)]+ (where M = ReI or 99mTcI; Lx = 1,4-substituted pyridyl-1,2,3-triazole ligands and py = pyridine) were prepared. One rhenium complex has been characterized by X-ray crystallography, and the luminescent properties of [M(CO)3Lx(py)]+ are reported.
- Subjects
TECHNETIUM compounds synthesis; RHENIUM compounds synthesis; PEPTIDE synthesis; LIGANDS (Biochemistry); ASPARTIC acid; ARGININE
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2014, Vol 57, Issue 4, p262
- ISSN
0362-4803
- Publication type
Article
- DOI
10.1002/jlcr.3169