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- Title
Nobel Prize for physiology or medicine in 2023: how to dupe the cellular innate immune system using modified RNA for therapeutic treatment.
- Authors
Medenbach, Jan; Tschochner, Herbert
- Abstract
The 2023 Nobel Prize in physiology or medicine was awarded to Katalin Karikó and Drew Weissman for their discoveries in using modified RNA for therapeutic treatments. This breakthrough enabled the development of COVID-19 RNA vaccines by Pfizer-BioNTech and Moderna. RNA is a versatile molecule that plays a central role in gene expression and regulation. Synthetic messenger RNAs (mRNAs) can be used as a template to program protein expression in human cells, making them ideal for vaccination. However, therapeutic RNAs lack the RNA-modification imprint of human cells, making them immunogenic. Karikó and Weissman discovered that introducing base modifications into mRNA during synthesis can suppress the immune response and improve translational capacity. These discoveries were crucial for the development of efficient mRNA-based vaccines for COVID-19 and mark a new era in vaccine development.
- Subjects
NOBEL Prize in Physiology or Medicine; GENETIC regulation; RNA; IMMUNE system; COVID-19 vaccines
- Publication
Pflügers Archiv: European Journal of Physiology, 2024, Vol 476, Issue 1, p5
- ISSN
0031-6768
- Publication type
Article
- DOI
10.1007/s00424-023-02895-9